College of Computer, Mathematical, and Natural Sciences

Kan Cao

Kan Cao

Assistant Professor

Contact

Email: kcao@umd.edu
Office Phone: 301.405.3016
Lab Phone: 301.405.3408
Lab: 2219 Bioscience Research Building
Office Address: 2114 Bioscience Research Building

Graduate Program Affiliations

  • BISI - BISI-Molecular & Cellular Biology (MOCB)

Research Interests

Hutchinson Gilford progeria syndrome, cellular senescence, alternative splicing and human aging

Recent Publications  (# Corresponding author, $ Graduate student, &Undergraduates) 

2014
1. Wu D$, Flannery A, Cai H&, Ko E, and Cao K# (2014). Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting. Nucleus Feb 4; 5 (1).  (Highlighted on the cover!)
 
2. Wang K$, Sahu A, Xiong Z, Cao K# and Hannenhalli S# (2014). Phenotype-dependent coexpression gene clusters: application to normal and premature ageing. (Under revision for Transactions on Computational Biology and Bioinformatics).
 
3. Zhang H$, Xiong Z and Cao K# (2014). Mechenisms controlling smooth mucle cell death in progeria via downregulation of Ploy (ADP-ribose) polymerase. Proceedings of the National Academy of Sciences (in press).

2013

1. Candia J, Maunu R, Driscoll M, Biancotto A, Dagur P, McCoy JP, Sen HN,Wei L, Maritan A, Cao K, Nussenblatt RB, Banavar JR, Losert W (2013) From Cellular Characteristics to Disease Diagnosis: Uncovering Phenotyps with Supercells. PLOS Computational Biology  9(9): e1003215. doi:10.1371/journal.pcbi.1003215.

2. Wang K$, Sahu A, Xiong Z, Cao K# and Hannenhalli S# (2013). Identification of gene clusters with phenotype dependant expression with application to normal and premature aging. ACM BCB (in press).

3. Xiong Z, LaDana C, Wu D$, and Cao K# (2013). An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells. Aging April 5(4): 288-303.

4. McCord R, Nazario-Toole A$, Zhang H$, Chines P, Zhan Y, Erdos MR, Collins FS, Dekker J, and Cao K#. (2013) Correlated Alterations in Genome Organization, Histone Methylation, and DNA-Lamin A/C Interactions in Hutchinson-Gilford Progeria Syndrome. Genome Research Feb; 23(2): 260-9. PMID: 23152449 

5. Zhang H$, Kieckhaefer JE, Cao K#. (2013) Mouse Models of Laminopathies. Aging Cell. pp1-9. DOI: 10.1111/acel.12021.PMID: 23095062

2012

1. Gordon LB, Cao K, and Collins FS. (2012) Progeria: Translational Insights from Cell Biology. The Journal of Cell Biology, 199(1):9-13.PMID: 23027899

2. Cao K#. (2012) Cellular Basis of Laminopathies. Encyclopedia of Life Sciences (eLS). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0022533.

3. Driscoll MK$, Albanese J&, Xiong ZM, Mailman M, Losert W#, and Cao K#. (2012). A novel automated image analysis of nuclear shape: What can we learn from a prematurely aged cell? Aging, Vol. 4, No 2. PMID: 22354768

4. Graziotto J, Cao K, Collins FS, and Krainc D. (2012) Rapamycin activates autophagy in Hutchinson-Gilford Progeria Syndrome: Implications for normal aging and age-dependent neurodegenerative disorders. Autophagy, 8(1).PMID: 22170152

2011

1. Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, and Collins FS. (2011) Lamin A and telomerase collaborate to trigger cellular senescence. Journal of Clinical Investigation, 121(7):2833-44.PMID: 21670498

2. Cao K*, Graziotto J*, Blair CD, Mazzulli JR, Erdos MR, Krainc D, and Collins FS. (2011) Rapamycin reverses cellular phenotype and enhances mutant protein clearance in Hutchinson Gilford progeria syndrome. Science Translational Medicine, 29;3(89):89ra58. (*: Equal contributors).PMID: 21715679

Before 2010

1. Olive M, Harten I, Mitchell R, Beers J, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. (2010) Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging. Arterioscler Thromb Vasc Biol., 30:2301.PMID: 20798379

2. Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Whipperman M, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Kolodgie KD, Virmani R, Nabel EG, Collins FS. (2009) A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proceedings of the National Academy of Sciences, 105(41):15902-7. PMID: 18838683

3. Cao K, Capell BC, Erdos MR, Djabali K, and Collins FS. (2007) A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proceedings of the National Academy of Sciences, 104(12) 4949-4954.PMID: 17360355

4. Vong QP*, Cao K*, Li HY, Iglesias PA, Zheng Y. (2005). Chromosome alignment and segregation regulated by ubiquitination of survivin. Science, 310(5753): 1499-504. (*:Equal contributors).

5. Cao K and Zheng Y. (2004). The Cdc48/p97-Ufd1-Npl4 Complex: Its Potential Role in Coordinating Cellular Morphogenesis During the M-G (1) Transition. Cell Cycle, 3:422-424.

6. Cao K, Nakajima R, Meyer HH, Zheng Y. (2003). The AAA-ATPase Cdc48/p97 Regulates Spindle Disassembly at the End of Mitosis. Cell, 115:355-367. 

7. Li HY*, Cao K*, Zheng Y. (2003). Ran in the Spindle Checkpoint: A New Function for A Versatile GTPase. Trends in Cell Biology, 13:553-557. (*: Equal contributors).

8. Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, 
Zheng Y. (2003) A Ran Signaling Pathway Mediated by the Mitotic Kinase Aurora A in Spindle Assembly. Nature Cell Biology, 5:242-248.

9. Gunawardane R, Martin O, Cao K, Zhang L, Dej K, Iwamatsu A, and Zheng Y. (2000) Characterization and Reconstitution of Drosophila gamma-Tubulin Ring Complex Subunits. The Journal of Cell Biology, 151:1513-23.

Teaching

BSCI330: Spring Semester

CBMG668: Fall Semester

Education

Ph. D. Johns Hopkins University, 2005