Kan Cao

Assistant Professor

1. McCord R, Nazario-Toole A, Chines P, Zhan Y, Erdos MR, Collins FS, Dekker J, and Cao K. (2012) Alterations in DNA and Nuclear Lamina Interactions and Nuclear Organization in Hutchinson-Gilford Progeria Syndrome. (in revision)

2. Cao K. (2012) Cellular Basis of Laminopathies. Encyclopedia of Life Sciences (eLS). (Accepted)

3. Driscoll MK, Albanese J, Xiong ZM, Mailman M, Losert W, and Cao K. (2012). A novel automated image analysis of nuclear shape: What can we learn from a prematurely aged cell? Aging 2012 Feb, Vol. 4, No 2.

4. Graziotto J, Cao K, Collins FS, and Krainc D. (2012) Rapamycin activates autophagy in Hutchinson-Gilford Progeria Syndrome: Implications for normal aging and age-dependent neurodegenerative disorders. Autophagy, 2012 Jan 1;8(1).

2011

1. Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, and Collins FS. (2011) Lamin A and telomerase collaborate to trigger cellular senescence. Journal of Clinical Investigation. Jul 1;121(7):2833-44.

2. Cao K*, Graziotto J*, Blair CD, Mazzulli JR, Erdos MR, Krainc D, and Collins FS. (2011) Rapamycin reverses cellular phenotype and enhances mutant protein clearance in Hutchinson Gilford progeria syndrome. Science Translational Medicine. 29;3(89):89ra58. (*: Equal contributors).

Before 2010

1. Olive M, Harten I, Mitchell R, Beers J, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. (2010) Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging. Arterioscler Thromb Vasc Biol., 30:2301.

2. Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Whipperman M, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Kolodgie KD, Virmani R, Nabel EG, Collins FS. (2008) A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proceedings of the National Academy of Sciences, 105(41):15902-7.

3. Cao K, Capell BC, Erdos MR, Djabali K, and Collins FS. (2007) A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proceedings of the National Academy of Sciences, 104(12) 4949-4954. (Highlights: Nature 446, 472-473 2007; Nature Reviews Molecular Cell Biology Vol 8(5), 34 2007)

4. Vong QP*, Cao K*, Li HY, Iglesias PA, Zheng Y. (2005). Chromosome alignment and segregation regulated by ubiquitination of survivin. Science, 310(5753): 1499-504. (*:Equal contributors). (Perspective: Science 310, 1443-1444 2005)

5. Cao K and Zheng Y. (2004). The Cdc48/p97-Ufd1-Npl4 Complex: Its Potential Role in Coordinating Cellular Morphogenesis During the M-G (1) Transition. Cell Cycle, 3:422-424.

6. Cao K, Nakajima R, Meyer HH, Zheng Y. (2003). The AAA-ATPase Cdc48/p97 Regulates Spindle Disassembly at the End of Mitosis. Cell, 115:355-367. (Commentary: Cheeseman and Desai, Current Biology 14, R70-72 2004).

7. Li HY*, Cao K*, Zheng Y. (2003). Ran in the Spindle Checkpoint: A New Function for A Versatile GTPase. Trends in Cell Biology, 13:553-557. (*: Equal contributors).

8. Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, 
Zheng Y. (2003) A Ran Signaling Pathway Mediated by the Mitotic Kinase Aurora A in Spindle Assembly. Nature Cell Biology, 5:242-248.

9. Gunawardane R, Martin O, Cao K, Zhang L, Dej K, Iwamatsu A, and Zheng Y. (2000) Characterization and Reconstitution of Drosophila gamma-Tubulin Ring Complex Subunits. The Journal of Cell Biology, 151:1513-23.